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Indian J Exp Biol ; 1991 Jun; 29(6): 574-8
Article in English | IMSEAR | ID: sea-56471

ABSTRACT

There is a correlation between phylogeny and the activities of L-gulonolactone oxidase (LGO), the key enzyme responsible for ascorbic acid (AH2) synthesis in animals and total xanthine oxidase and dehydrogenase [XOD(D/O)], the enzyme responsible for the production of endogenous superoxide radical (O2-.). LGO appears in the kidneys of amphibians and reptiles but livers of mammals. XOD(D/O) also is present mainly in the kidneys of amphibians and reptiles and livers of mammals. AH2 is a potential scavenger of O2-. and it appears that tissue specific expression of LGO takes place to counteract the endogenous O2-. toxicity. The interrelation of XOD(D/O) and LGO was also observed in the liver of rats during prenatal to postnatal development.


Subject(s)
Animals , Anura , L-Gulonolactone Oxidase , Liver/growth & development , Mammals , Oxygen/metabolism , Reptiles , Sugar Alcohol Dehydrogenases/metabolism , Xanthine Dehydrogenase/metabolism , Xanthine Oxidase/metabolism
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